| Date | Location | Result | |
| 02-25-11 | Hanover, Ind. | Manchester 74, Defiance 62 | Box score |
| 02-19-11 | Defiance, Ohio | Defiance 83, Franklin 81 | Box score |
| 02-16-11 | Defiance, Ohio | Defiance 73, Bluffton 63 | Box score |
| 02-12-11 | Defiance, Ohio | Mount St. Joseph 99, Defiance 92 | Box score |
| 02-09-11 | Richmond, Ind. | Defiance 81, Earlham 56 | Box score |
| 02-05-11 | Lexington, Ky. | Transylvania 104, Defiance 64 | Box score |
| 02-03-11 | N. Manchester, Ind. | Defiance 85, Manchester 76 | Box score |
| 01-29-11 | Hanover, Ind. | Hanover 102, Defiance 91 | Box score |
| 01-26-11 | Defiance, Ohio | Defiance 69, Anderson 67 | Box score |
| 01-22-11 | Defiance, Ohio | Defiance 79, Rose-Hulman 72 | Box score |
| 01-19-11 | Bluffton, Ohio | Bluffton 90, Defiance 83 | Box score |
| 01-15-11 | Franklin, Ind. | Franklin 73, Defiance 60 | Box score |
| 01-12-11 | Defiance, Ohio | Defiance 100, Earlham 83 | Box score |
| 01-08-11 | Cincinnati, Ohio | Defiance 73, Mount St. Joseph 71 | Box score |
| 01-05-11 | Defiance, Ohio | Transylvania 58, Defiance 48 | Box score |
| 12-30-10 | Wooster, Ohio | Defiance 53, Wooster 38 | Box score |
| 12-18-10 | Defiance, Ohio | Defiance 85, Brescia 74 | Box score |
| 12-17-10 | Defiance, Ohio | Allegheny 103, Defiance 100 | Box score |
| 12-11-10 | Defiance, Ohio | Hanover 92, Defiance 75 | Box score |
| 12-08-10 | Defiance, Ohio | Manchester 85, Defiance 74 | Box score |
| 12-04-10 | Terre Haute, Ind. | Defiance 67, Rose-Hulman 50 | Box score |
| 12-01-10 | Anderson, Ind. | Defiance 75, Anderson 63 | Box score |
| 11-23-10 | Defiance, Ohio | Hope 76, Defiance 56 | Box score |
| 11-20-10 | Wilmington, Ohio | Ohio Wesleyan 76, Defiance 63 | Box score |
| 11-19-10 | Wilmington, Ohio | Wilmington 60, Defiance 56 | Box score |
| 11-16-10 | Olivet, Mich. | Olivet 57, Defiance 53 | Box score |