| Date | Location | Result | |
| 02-24-12 | Franklin, IN | Transylvania 57, Defiance 42 | Box score |
| 02-18-12 | Defiance, OH | Franklin 61, Defiance 52 | Box score |
| 02-15-12 | Defiance, OH | Defiance 77, Bluffton 68 | Box score |
| 02-11-12 | Terre Haute, IN | Rose-Hulman 60, Defiance 33 | Box score |
| 02-08-12 | Defiance, OH | Defiance 70, Earlham 57 | Box score |
| 02-04-12 | Defiance,OH | Defiance 71, Mount St. Joseph 55 | Box score |
| 02-01-12 | N. Manchester, IN | Manchester 41, Defiance 34 | Box score |
| 01-28-12 | Lexington, KY | Transylvania 69, Defiance 66 | Box score |
| 01-25-12 | Defiance, OH | Defiance 62, Anderson 54 | Box score |
| 01-21-12 | Defiance, OH | Hanover 74, Defiance 66 | Box score |
| 01-18-12 | Richmond, IN | Defiance 81, Earlham 73 | Box score |
| 01-14-12 | Cincinnati, OH | Defiance 69, Mount St. Joseph 56 | Box score |
| 01-11-12 | Defiance, OH | Manchester 58, Defiance 47 | Box score |
| 01-07-12 | Defiance, OH | Transylvania 60, Defiance 53 | Box score |
| 01-04-12 | Bluffton, OH | Defiance 63, Bluffton 53 | Box score |
| 12-21-11 | Alma, MI | Alma 65, Defiance 48 | Box score |
| 12-19-11 | Anderson, IN | Defiance 55, Anderson 50 | Box score |
| 12-17-11 | Defiance, OH | Albion 78, Defiance 58 | Box score |
| 12-14-11 | Defiance, OH | Defiance 70, Kalamazoo 65 | Box score |
| 12-10-11 | Hanover, IN | Hanover 71, Defiance 49 | Box score |
| 12-03-11 | Defiance, OH | Defiance 66, Rose-Hulman 54 | Box score |
| 11-30-11 | Franklin, IN | Franklin 74, Defiance 60 | Box score |
| 11-22-11 | Holland, MI | Hope 68, Defiance 43 | Box score |
| 11-19-11 | Washington, PA | Defiance 75, Pitt-Greensburg 51 | Box score |
| 11-18-11 | Washington, PA | Otterbein 58, Defiance 49 | Box score |
| 11-15-11 | Defiance, OH | Olivet 58, Defiance 52 | Box score |