| Date | Location | Result | |
| 11-13-10 | Bluffton, OH | Bluffton 21, Defiance 16 | Box score |
| 11-06-10 | N. Manchester, IN | Defiance 10, Manchester 7 | Box score |
| 10-30-10 | Defiance, OH | Defiance 41, Rose-Hulman 21 | Box score |
| 10-23-10 | Defiance, OH | Defiance 49, Anderson 7 | Box score |
| 10-16-10 | Richmond, IN | Defiance 33, Earlham 0 | Box score |
| 10-09-10 | Defiance, OH | Defiance 22, Mt. St. Joseph 14 | Box score |
| 09-25-10 | Defiance, OH | Franklin 42, Defiance 7 | Box score |
| 09-18-10 | Hanover, IN | Defiance 24, Hanover 10 | Box score |
| 09-11-10 | Adrian, MI | Adrian 40, Defiance 14 | Box score |
| 09-04-10 | New Concord, OH | Muskingum 19, Defiance 13 | Box score |