| Date | Location | Result | |
| 11-12-11 | Defiance, OH | Bluffton 46, Defiance 27 | Box score |
| 11-05-11 | Defiance, OH | Manchester 32, Defiance 6 | Box score |
| 10-29-11 | Terre Haute, IN | Defiance 21, Rose-Hulman 18 | Box score |
| 10-22-11 | Anderson, IN | Defiance 28, Anderson 21 | Box score |
| 10-15-11 | Defiance, OH | Defiance 26, Earlham 10 | Box score |
| 10-08-11 | Cincinnati, OH | Defiance 23, Mount St. Joseph 13 | Box score |
| 09-24-11 | Franklin, IN | Franklin 52, Defiance 14 | Box score |
| 09-17-11 | Defiance, OH | Hanover 37, Defiance 12 | Box score |
| 09-10-11 | Defiance, OH | Adrian 27, Defiance 6 | Box score |
| 09-03-11 | Defiance, OH | Muskingum 24, Defiance 7 | Box score |