| Date | Location | Result | |
| 03-05-10 | Wooster, OH | UW-Whitewater 75, Defiance 71 | Box score |
| 02-27-10 | Anderson, IN | Defiance 70, Anderson 65 | Box score |
| 02-26-10 | Anderson, IN | Defiance 72, Hanover 59 | Box score |
| 02-23-10 | Defiance, OH | Defiance 92, Franklin 78 | Box score |
| 02-20-10 | Franklin, IN | Defiance 73, Franklin 60 | Box score |
| 02-17-10 | Defiance, OH | Defiance 70, Bluffton University 60 | Box score |
| 02-13-10 | Defiance, OH | Defiance 83, College of Mount St. Joseph 64 | Box score |
| 02-06-10 | Defiance, OH | Defiance 71, Transylvania 64 | Box score |
| 02-03-10 | N. Manchester, IN | Defiance 70, Manchester 59 | Box score |
| 01-30-10 | Defiance, OH | Hanover 78, Defiance 70 | Box score |
| 01-27-10 | Defiance, OH | Defiance 91, Anderson 75 | Box score |
| 01-23-10 | Terre Haute, IN | Defiance 61, Rose-Hulman 57 | Box score |
| 01-20-10 | Bluffton, OH | Bluffton University 91, Defiance 83 | Box score |
| 01-16-10 | Defiance, OH | Defiance 99, Franklin 83 | Box score |
| 01-09-10 | Cincinnati, OH | Defiance 81, College of Mount St. Joseph 72 | Box score |
| 01-06-10 | Lexington, KY | Transylvania 58, Defiance 56 | Box score |
| 01-03-10 | Salem, VA | Defiance 64, Ohio Wesleyan 56 | Box score |
| 01-02-10 | Salem, VA | Defiance 87, Ferrum 85 | Box score |
| 12-30-09 | Defiance, OH | Defiance 89, DePauw 75 | Box score |
| 12-29-09 | Defiance, OH | Defiance 114, Ohio State-Lima 51 | Box score |
| 12-16-09 | Defiance, OH | Defiance 90, Madonna 79 | Box score |
| 12-12-09 | Hanover, IN | Hanover 79, Defiance 73 | Box score |
| 12-09-09 | Defiance, OH | Defiance 95, Manchester 82 | Box score |
| 12-05-09 | Defiance, OH | Defiance 82, Rose-Hulman 61 | Box score |
| 12-02-09 | Anderson, IN | Anderson 88, Defiance 70 | Box score |
| 11-24-09 | Defiance, OH | Defiance 74, Ohio Wesleyan 71 | Box score |
| 11-22-09 | Adrian, MI | Defiance 79, Adrian 72 | Box score |
| 11-21-09 | Adrian, MI | Defiance 80, Mount Union 67 | Box score |
| 11-15-09 | Kalamazoo, MI | Defiance 79, Kalamazoo 62 | Box score |